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Emerging incidence trends of eosinophilic esophagitis over 25 years: Results of a nationwide register-based pathology cohort
De Rooij and coworkers have shown that the incidence of EoE is still ever increasing. These authors performed a search of the nationwide register-based pathology (PALGA) in the Netherlands to identify reports describing esophageal eosinophilia between 1995 and 2019. The EoE incidence increased from 0.01 in 1995 to 3.16 per 100.000 inhabitants in 2019. EoE was significantly more prevalent in males (OR 2.48) and adults (OR 1.42 vs. children). Highest incidences were observed in the final year of the search, 2019, being 4.37 per 100.000 males and females. No seasonal variation was observed in diagnosis. It stresses that over the past quarter century, the annual rates of newly diagnosed EoE patients raised dramatically and this increase has not reached a deceleration yet.