This article from a collaborative group of European and American physicians describes a new syndrome, often encountered in overlap with EoE. The so-called Food-induced immediate response of the esophagus (FIRE) is a phenomenon of an unpleasant/painful sensation, unrelated to dysphagia, occurring immediately after esophageal contact with specific foods. Forty percent of EoE patients reported experiencing FIRE, more commonly in patients who developed EoE symptoms at a younger age and in those with high allergic comorbidity. Food-induced immediate response of the esophagus symptoms included narrowing, burning, choking, and pressure in the esophagus appearing within 5 minutes of ingesting a provoking food that lasted less than 2 hours. Fresh fruits/vegetables and wine were the most frequent triggers. Endoscopic food removal was significantly more commonly reported in male patients with vs without FIRE. We expect more research to be performed on this phenomenon in the near future.